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5 from 5 votes

Blueberry Cheesecake French Toast Casserole (Make-Ahead)

This Blueberry Cheesecake French Toast Casserole features thick cubes of brioche soaked in a rich maple custard and layered with a tangy, decadent cream cheese swirl. Bursting with fresh lemon-kissed blueberries and finished with a buttery cinnamon streusel, it’s the ultimate make-ahead breakfast for any holiday morning. Simply prep it the night before and bake it until golden brown for a crowd-pleasing brunch that tastes exactly like a gourmet blueberry cheesecake.
Prep Time20 minutes
Cook Time30 minutes
Total Time50 minutes
Course: Breakfast
Cuisine: American
Keyword: Best Blueberry Brunch Bake, Blueberry Cheesecake Breakfast, Blueberry French Toast Casserole, Cream Cheese French Toast Recipe, Crowd-Pleasing Breakfast Casserole, Easy Christmas Brunch Ideas, French Toast Casserole with Streusel, Holiday Breakfast Recipes, Make-Ahead Breakfast Casserole, Overnight French Toast Bake
Servings: 8 servings
Calories: 1312kcal

Ingredients

The Cream Cheese Swirl

  • 2 (8-oz) bricks Cream Cheese
  • Cup Powdered Sugar
  • 4 tbsp Milk
  • 2 tsp Vanilla Extract

The Blueberries

  • 3 Cups Blueberries (divided)
  • 4 tbsp Sugar
  • 2 tbsp Lemon Juice

The Bread & Custard

  • 12 cups French Bread (day-old bread - allow it to dry out a bit)
  • 10 Eggs (beaten)
  • Cups Milk
  • ½ Cup Heavy Cream
  • 1 tsp Cinnamon
  • ½ tsp Nutmeg
  • 1 tbsp Vanilla Extract
  • ½ Cup Maple Syrup

The Crunchy Streusel

  • ½ Cup Flour
  • Cup Brown Sugar
  • ½ tsp Cinnamon
  • 4 tbsp Butter (cold)(cubed)

Instructions

  • Prepare the Baking Dish: Grease a 9x13-inch baking dish generously with butter or non-stick cooking spray.
  • Layer the Bread: Place half of the cubed French bread (approximately 6 cups) into the bottom of the prepared dish in an even layer.
  • Mix the Cheesecake Swirl: In a medium mixing bowl, beat the softened cream cheese, powdered sugar, 4 tablespoons of milk, and 2 teaspoons of vanilla extract until smooth.
  • Add the First Layer: Drop spoonfuls of half the cream cheese mixture over the bread cubes. In a separate small bowl, toss the blueberries with 4 tablespoons of sugar and 2 tablespoons of lemon juice. Scatter half of this berry mixture over the cream cheese.
  • Repeat Layers: Add the remaining bread cubes to the dish. Top with the remaining cream cheese mixture and the rest of the blueberries.
  • Whisk the Custard: In a large bowl, whisk together the 10 eggs, milk, heavy cream, cinnamon, nutmeg, 1 tablespoon of vanilla, and maple syrup until well combined.
  • Saturate the Bread: Slowly pour the custard mixture over the bread, ensuring all pieces are evenly coated.
  • The Soak: Cover the dish tightly with foil. For best results, refrigerate overnight (8–12 hours). If making the same day, allow the dish to sit for at least 30–45 minutes to allow the bread to absorb the custard.
  • Prepare the Streusel: Preheat the oven to 350°F. In a small bowl, combine the flour, brown sugar, and cinnamon. Use a fork or pastry cutter to cut in the cold, cubed butter until the mixture resembles coarse crumbs.
  • Bake: Sprinkle the streusel evenly over the top of the casserole. Bake uncovered for 45–55 minutes. The casserole is done when the center is set and the top is golden brown.
  • Rest and Serve: Allow the casserole to rest for 10 minutes before slicing to let the custard fully set. Serve warm with extra maple syrup if desired.

Nutrition

Calories: 1312kcal | Carbohydrates: 215g | Protein: 40g | Fat: 34g | Saturated Fat: 10g | Polyunsaturated Fat: 2g | Monounsaturated Fat: 5g | Trans Fat: 0.3g | Cholesterol: 247mg | Sodium: 2177mg | Potassium: 330mg | Fiber: 14g | Sugar: 56g | Vitamin A: 861IU | Vitamin C: 7mg | Calcium: 194mg | Iron: 2mg